Info
| ID | 68 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru9 |
| SMILES | CC#N.CC#N.Fc1c(F)c(F)c(C[n+]2[c-]n(-c3ccccn3)cc2)c(F)c1F.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C31H22F5N7Ru/(1-29)(2-23)(3-23)(4-23)(5-44)(6-39)(7-25)(8-27)(9-44)(10-42)(11-26)(12-32)(13-33)(14-31)(15-30)(16-24)(17-40)(18-43)(19-41)(20-28)(21-24)(22-24)(23-37)(24-38)(25-26)(25-39)(26-34)(27-31)(27-34)(28-30)(28-43)(29-33)(29-48)(30-35)(31-35)(32-33)(32-41)(34-45)(35-46)(36-44)(36-50)(36-51)(37-54)(38-55)(39-58)(40-42)(40-56)(41-60)(42-57)(43-59)(44-57)(45-46)(45-58)(46-59)(47-56)(47-57)(48-56)(48-60)(49-50)(49-53)(49-62)(50-61)(51-52)(51-65)(52-53)(52-63)(53-64)(58-66)(59-66)(60-66)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 6.9 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 12 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 18 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 22 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 25 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | 28 | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»