Info
| ID | 678 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 3} |
| Abbreviation | 4d |
| SMILES | CCCCN1C(=N\c2ccccc2)/C(=N/c2ccccc2)c2ccccc21.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C34H37N3Ru/(1-54)(2-41)(3-65)(4-38)(5-38)(6-42)(7-38)(8-50)(9-45)(10-53)(11-39)(12-43)(13-39)(14-58)(15-49)(16-59)(17-52)(18-46)(19-47)(20-39)(21-61)(22-61)(23-60)(24-60)(25-48)(26-66)(27-40)(28-40)(29-40)(30-55)(31-41)(32-41)(33-44)(34-57)(35-56)(36-51)(37-66)(38-65)(39-65)(40-61)(41-63)(42-43)(42-63)(43-62)(44-52)(44-62)(45-46)(45-49)(46-47)(47-59)(48-54)(48-70)(49-69)(50-51)(50-53)(51-68)(52-63)(53-58)(54-55)(55-56)(56-57)(57-70)(58-64)(59-69)(60-61)(60-66)(62-65)(64-67)(64-68)(66-72)(67-71)(67-73)(68-72)(69-73)(70-74)(71-72)(71-74)(73-75)(74-75)
Measurements (4)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | 0.19 | — | 10.1021/acsomega.3c10265 | 2024 |
| MCF-7 | 0.54 | — | 10.1021/acsomega.3c10265 | 2024 |
| HEK293 | 22 | — | 10.1021/acsomega.3c10265 | 2024 |
| PC-3 | 55 | — | 10.1021/acsomega.3c10265 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Treatment of the cells with 4d induced a strong apoptotic effect on them (see Figure 3). Levels of the apoptosis-related proteins Bcl-2 and Bax were evaluated via Western blot analysis to confirm the ...»