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Complex #678 — Ru(2) [4d]

2D Structure

Structure
⬇ MOL V3000

Info

ID678
MetalRu
Oxidation state2
Charge1
Donor atoms{"N": 3}
Abbreviation4d
SMILESCCCCN1C(=N\c2ccccc2)/C(=N/c2ccccc2)c2ccccc21.Cc1ccc(C(C)C)cc1.[Cl-]

TUCAN

C34H37N3Ru/(1-54)(2-41)(3-65)(4-38)(5-38)(6-42)(7-38)(8-50)(9-45)(10-53)(11-39)(12-43)(13-39)(14-58)(15-49)(16-59)(17-52)(18-46)(19-47)(20-39)(21-61)(22-61)(23-60)(24-60)(25-48)(26-66)(27-40)(28-40)(29-40)(30-55)(31-41)(32-41)(33-44)(34-57)(35-56)(36-51)(37-66)(38-65)(39-65)(40-61)(41-63)(42-43)(42-63)(43-62)(44-52)(44-62)(45-46)(45-49)(46-47)(47-59)(48-54)(48-70)(49-69)(50-51)(50-53)(51-68)(52-63)(53-58)(54-55)(55-56)(56-57)(57-70)(58-64)(59-69)(60-61)(60-66)(62-65)(64-67)(64-68)(66-72)(67-71)(67-73)(68-72)(69-73)(70-74)(71-72)(71-74)(73-75)(74-75)

Measurements (4)

Cell lineIC₅₀ dark (µM)IC₅₀ light (µM)DOIYear
HepG20.19 10.1021/acsomega.3c10265 2024
MCF-70.54 10.1021/acsomega.3c10265 2024
HEK29322 10.1021/acsomega.3c10265 2024
PC-355 10.1021/acsomega.3c10265 2024

🧬 Cell Death Types (1)

Apoptosis high
«Treatment of the cells with 4d induced a strong apoptotic effect on them (see Figure 3). Levels of the apoptosis-related proteins Bcl-2 and Bax were evaluated via Western blot analysis to confirm the ...»