Info
| ID | 67 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru8 |
| SMILES | CC#N.CC#N.Cc1c(C)c(C)c(C[n+]2[c-]n(-c3ccccn3)cc2)c(C)c1C.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C36H37N7Ru/(1-38)(2-47)(3-38)(4-66)(5-42)(6-38)(7-39)(8-39)(9-39)(10-44)(11-48)(12-51)(13-45)(14-44)(15-69)(16-68)(17-67)(18-43)(19-43)(20-44)(21-43)(22-42)(23-42)(24-40)(25-40)(26-40)(27-41)(28-41)(29-41)(30-65)(31-46)(32-50)(33-53)(34-69)(35-52)(36-64)(37-49)(38-56)(39-57)(40-62)(41-63)(42-58)(43-61)(44-59)(45-47)(45-66)(46-49)(46-67)(47-54)(48-51)(48-54)(49-60)(50-52)(50-68)(51-60)(52-53)(53-73)(54-70)(55-56)(55-59)(55-69)(56-57)(57-58)(58-61)(59-61)(60-71)(62-74)(63-75)(64-65)(64-77)(65-76)(66-78)(67-79)(68-80)(69-76)(70-71)(70-78)(71-79)(72-76)(72-77)(73-77)(73-80)(78-81)(79-81)(80-81)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 3.3 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 4.7 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 5.1 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 10 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 15 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | 16 | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»