Info
| ID | 6673 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 1} |
| Abbreviation | 5 |
| SMILES | Cc1ccc(C(C)C)cc1.O=C(CCc1cccnc1)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[Cl-].[Cl-] |
TUCAN
C26Cl2F13NO2Os/(1-14)(2-13)(3-13)(4-7)(4-15)(5-6)(5-16)(6-20)(7-14)(8-9)(8-14)(9-15)(10-11)(10-16)(11-17)(12-19)(12-25)(13-15)(16-18)(17-27)(18-27)(19-29)(20-28)(20-29)(21-22)(21-25)(21-31)(21-32)(22-23)(22-33)(22-34)(23-24)(23-35)(23-36)(24-26)(24-37)(24-38)(25-30)(25-39)(26-40)(26-41)(26-42)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | — | — | 10.1002/cmdc.201500221 | 2015 |
| HEK293 | — | — | 10.1002/cmdc.201500221 | 2015 |
| ECRF24 | — | — | 10.1002/cmdc.201500221 | 2015 |
🧬 Cell Death Types (1)
Apoptosis
high
«Induction of apoptosis was most pronounced for 4 (58.3%) and 7 (52.4%), administrated at a dose of 50 mm. ... This revealed that a significant sub-population of the cells undergoes apoptosis (Table3).»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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