Info
| ID | 66 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru7 |
| SMILES | CC#N.CC#N.Cc1c(C)c(C)c(C[n+]2[c-]n(-c3ccccn3)cc2)c(C)c1C.Cc1ccc(-c2ccc(C)cn2)nc1 |
TUCAN
C36H41N7Ru/(1-69)(2-54)(3-51)(4-55)(5-48)(6-47)(7-48)(8-73)(9-42)(10-42)(11-57)(12-42)(13-56)(14-47)(15-72)(16-48)(17-68)(18-73)(19-49)(20-47)(21-50)(22-46)(23-46)(24-44)(25-44)(26-44)(27-45)(28-45)(29-45)(30-52)(31-49)(32-50)(33-43)(34-43)(35-49)(36-70)(37-53)(38-43)(39-71)(40-46)(41-50)(42-58)(43-59)(44-66)(45-67)(46-61)(47-60)(48-64)(49-65)(50-62)(51-52)(51-69)(52-53)(53-77)(54-55)(54-58)(55-74)(56-57)(56-75)(57-59)(58-68)(59-71)(60-61)(60-64)(61-62)(62-65)(63-64)(63-65)(63-73)(66-78)(67-79)(68-82)(69-84)(70-72)(70-81)(71-83)(72-80)(73-81)(74-75)(74-82)(75-83)(76-80)(76-81)(77-80)(77-84)(82-85)(83-85)(84-85)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 5.7 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 9.5 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 10 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 20 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | 25 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 33 | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»