Info
| ID | 6523 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 2} |
| Abbreviation | 6 |
| SMILES | CC(=O)[O-].CCCCn1c(-c2[c-]cc(-c3ccccc3)cc2)nc2cc(C(=O)OC)ccc21.Cc1ccc(C(C)C)cc1 |
TUCAN
C37H40N2O4Os/(1-71)(2-41)(3-41)(4-41)(5-63)(6-42)(7-44)(8-48)(9-54)(10-55)(11-57)(12-58)(13-52)(14-61)(15-60)(16-75)(17-51)(18-44)(19-47)(20-44)(21-49)(22-50)(23-70)(24-59)(25-42)(26-45)(27-63)(28-45)(29-45)(30-62)(31-56)(32-75)(33-42)(34-71)(35-62)(36-75)(37-53)(38-43)(39-43)(40-43)(41-70)(42-65)(43-76)(44-70)(45-63)(46-54)(46-64)(47-48)(47-65)(48-69)(49-50)(49-69)(50-65)(51-59)(51-68)(52-55)(52-66)(53-61)(53-66)(54-67)(55-58)(56-60)(56-67)(57-68)(57-73)(58-61)(59-72)(60-64)(62-63)(62-71)(64-74)(66-67)(68-77)(69-70)(71-78)(72-73)(72-78)(73-79)(74-78)(74-79)(75-83)(76-80)(76-82)(77-81)(77-83)(79-84)(83-84)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.76 | — | 10.1039/c8cc06427j | 2018 |
| A2780 | 0.98 | — | 10.1039/c8cc06427j | 2018 |
| A2780cisR | 1 | — | 10.1039/c8cc06427j | 2018 |
| BGM | 1.7 | — | 10.1039/c8cc06427j | 2018 |
| HCT-116 | 2.3 | — | 10.1039/c8cc06427j | 2018 |
| 518A2 | 3.1 | — | 10.1039/c8cc06427j | 2018 |
| EA.hy926 | 3.1 | — | 10.1039/c8cc06427j | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The ability of 2 and 3 to induce apoptosis in A2780 cells was also evaluated. As shown in Fig.2A, complexes 2 and 3 considerably increased the percentage of early apoptotic cells (Annexin V+/PI-) foll...»