Info
| ID | 6522 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1, "N": 2} |
| Abbreviation | 5 |
| SMILES | CC(=O)[O-].CCCCn1c(-c2[c-]cc(C(F)(F)F)cc2)nc2cc(C(=O)OC)ccc21.Cc1ccc(C(C)C)cc1 |
TUCAN
C32H35F3N2O4Os/(1-52)(2-36)(3-37)(4-37)(5-40)(6-49)(7-59)(8-36)(9-52)(10-60)(11-42)(12-43)(13-44)(14-37)(15-64)(16-45)(17-39)(18-46)(19-51)(20-39)(21-39)(22-36)(23-64)(24-64)(25-40)(26-40)(27-47)(28-48)(29-53)(30-53)(31-50)(32-60)(33-38)(34-38)(35-38)(36-57)(37-59)(38-65)(39-59)(40-53)(41-47)(41-54)(42-43)(42-55)(43-57)(44-51)(44-55)(45-56)(45-61)(46-49)(46-56)(47-58)(48-50)(48-54)(49-62)(50-58)(51-57)(52-53)(52-60)(54-63)(55-59)(56-66)(58-67)(60-68)(61-62)(61-69)(62-68)(63-68)(63-69)(64-73)(65-70)(65-72)(66-71)(66-73)(67-74)(67-75)(67-76)(69-77)(73-77)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 2 | — | 10.1039/c8cc06427j | 2018 |
| MCF-7 | 3.1 | — | 10.1039/c8cc06427j | 2018 |
| A2780cisR | 3.7 | — | 10.1039/c8cc06427j | 2018 |
| 518A2 | 6.9 | — | 10.1039/c8cc06427j | 2018 |
| BGM | 7.6 | — | 10.1039/c8cc06427j | 2018 |
| HCT-116 | 8.8 | — | 10.1039/c8cc06427j | 2018 |
| EA.hy926 | 9 | — | 10.1039/c8cc06427j | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The ability of 2 and 3 to induce apoptosis in A2780 cells was also evaluated. As shown in Fig.2A, complexes 2 and 3 considerably increased the percentage of early apoptotic cells (Annexin V+/PI-) foll...»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
Loading source metadata…
The generated SVG will appear here. The legacy ligand image above stays visible for side-by-side review.