Info
| ID | 6520 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 3 |
| SMILES | CCCCn1c(-c2[c-]cc(OC)cc2)nc2cc(C(=O)OC)ccc21.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C30H35N2O3Os/(1-63)(2-36)(3-38)(4-41)(5-48)(6-38)(7-42)(8-38)(9-46)(10-39)(11-44)(12-39)(13-39)(14-43)(15-57)(16-45)(17-36)(18-37)(19-52)(20-37)(21-49)(22-58)(23-58)(24-51)(25-51)(26-52)(27-63)(28-62)(29-62)(30-36)(31-50)(32-63)(33-62)(34-47)(35-37)(36-54)(37-52)(38-57)(39-57)(40-49)(40-56)(41-42)(41-53)(42-54)(43-44)(43-53)(44-54)(45-46)(45-59)(46-55)(47-55)(47-60)(48-50)(48-56)(49-64)(50-64)(51-52)(51-58)(53-57)(55-65)(56-61)(58-66)(59-60)(59-66)(60-67)(61-66)(61-67)(62-69)(63-70)(64-70)(65-68)(65-69)(67-71)(70-71)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 1.9 | — | 10.1039/c8cc06427j | 2018 |
| A2780 | 1.9 | — | 10.1039/c8cc06427j | 2018 |
| HCT-116 | 3.8 | — | 10.1039/c8cc06427j | 2018 |
| MCF-7 | 4.2 | — | 10.1039/c8cc06427j | 2018 |
| 518A2 | 4.8 | — | 10.1039/c8cc06427j | 2018 |
| EA.hy926 | 4.9 | — | 10.1039/c8cc06427j | 2018 |
| BGM | 11 | — | 10.1039/c8cc06427j | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The ability of 2 and 3 to induce apoptosis in A2780 cells was also evaluated. As shown in Fig.2A, complexes 2 and 3 considerably increased the percentage of early apoptotic cells (Annexin V+/PI-) foll...»