Info
| ID | 6519 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 2 |
| SMILES | CCCCn1c(-c2[c-]cc(C)cc2)nc2cc(C(=O)OC)ccc21.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C30H35N2O2Os/(1-40)(2-42)(3-36)(4-36)(5-39)(6-64)(7-64)(8-40)(9-64)(10-36)(11-37)(12-39)(13-37)(14-44)(15-43)(16-37)(17-59)(18-38)(19-38)(20-53)(21-53)(22-60)(23-52)(24-38)(25-40)(26-49)(27-60)(28-51)(29-47)(30-39)(31-48)(32-45)(33-50)(34-46)(35-52)(36-59)(37-59)(38-53)(39-56)(40-58)(41-49)(41-57)(42-43)(42-54)(43-56)(44-48)(44-54)(45-55)(45-62)(46-47)(46-55)(47-61)(48-56)(49-58)(50-51)(50-57)(51-58)(52-53)(52-60)(54-59)(55-65)(57-63)(60-66)(61-62)(61-66)(62-67)(63-66)(63-67)(64-69)(65-68)(65-69)(67-70)(69-70)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 1.8 | — | 10.1039/c8cc06427j | 2018 |
| A2780 | 2 | — | 10.1039/c8cc06427j | 2018 |
| MCF-7 | 3.7 | — | 10.1039/c8cc06427j | 2018 |
| HCT-116 | 3.8 | — | 10.1039/c8cc06427j | 2018 |
| 518A2 | 4.8 | — | 10.1039/c8cc06427j | 2018 |
| EA.hy926 | 4.9 | — | 10.1039/c8cc06427j | 2018 |
| BGM | 9.8 | — | 10.1039/c8cc06427j | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The ability of 2 and 3 to induce apoptosis in A2780 cells was also evaluated. As shown in Fig.2A, complexes 2 and 3 considerably increased the percentage of early apoptotic cells (Annexin V+/PI-) foll...»