Info
| ID | 6518 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"N": 2} |
| Abbreviation | 1 |
| SMILES | CCCCn1c(-c2[c-]cccc2)nc2cc(C(=O)OC)ccc21.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C29H33N2O2Os/(1-48)(2-39)(3-34)(4-34)(5-37)(6-61)(7-61)(8-61)(9-42)(10-34)(11-35)(12-37)(13-35)(14-40)(15-44)(16-35)(17-56)(18-36)(19-36)(20-51)(21-36)(22-50)(23-50)(24-49)(25-57)(26-57)(27-47)(28-37)(29-45)(30-41)(31-46)(32-43)(33-51)(34-56)(35-56)(36-51)(37-53)(38-49)(38-54)(39-44)(39-52)(40-45)(40-52)(41-55)(41-58)(42-43)(42-55)(43-59)(44-53)(45-53)(46-47)(46-54)(47-48)(48-49)(50-51)(50-57)(52-56)(54-60)(55-62)(57-63)(58-59)(58-64)(59-63)(60-63)(60-64)(61-66)(62-65)(62-66)(64-67)(66-67)
Measurements (7)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780cisR | 3.4 | — | 10.1039/c8cc06427j | 2018 |
| A2780 | 3.6 | — | 10.1039/c8cc06427j | 2018 |
| MCF-7 | 4.4 | — | 10.1039/c8cc06427j | 2018 |
| HCT-116 | 4.5 | — | 10.1039/c8cc06427j | 2018 |
| EA.hy926 | 5.7 | — | 10.1039/c8cc06427j | 2018 |
| 518A2 | 6.1 | — | 10.1039/c8cc06427j | 2018 |
| BGM | 14 | — | 10.1039/c8cc06427j | 2018 |
🧬 Cell Death Types (1)
Apoptosis
high
«The ability of 2 and 3 to induce apoptosis in A2780 cells was also evaluated. As shown in Fig.2A, complexes 2 and 3 considerably increased the percentage of early apoptotic cells (Annexin V+/PI-) foll...»