Info
| ID | 65 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru6 |
| SMILES | CC#N.CC#N.Cc1c(C)c(C)c(C[n+]2[c-]n(-c3ccccn3)cc2)c(C)c1C.c1ccc(-c2ccccn2)nc1 |
TUCAN
C34H37N7Ru/(1-38)(2-45)(3-38)(4-46)(5-42)(6-38)(7-39)(8-39)(9-39)(10-44)(11-50)(12-51)(13-47)(14-44)(15-53)(16-66)(17-62)(18-43)(19-43)(20-44)(21-43)(22-42)(23-42)(24-40)(25-40)(26-40)(27-41)(28-41)(29-41)(30-49)(31-67)(32-65)(33-64)(34-67)(35-52)(36-48)(37-63)(38-55)(39-56)(40-60)(41-61)(42-57)(43-59)(44-58)(45-46)(45-68)(46-47)(47-62)(48-51)(48-63)(49-52)(49-66)(50-51)(50-69)(52-53)(53-71)(54-55)(54-58)(54-67)(55-56)(56-57)(57-59)(58-59)(60-72)(61-73)(62-76)(63-77)(64-65)(64-75)(65-74)(66-78)(67-74)(68-69)(68-76)(69-77)(70-74)(70-75)(71-75)(71-78)(76-79)(77-79)(78-79)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 7.3 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 12 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 14 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 31 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 34 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | 39 | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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