Info
| ID | 6473 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 8 |
| SMILES | C(=N\CC/N=C\c1cc2cccc3ccc4cccc1c4c32)\c1cc2cccc3ccc4cccc1c4c32.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C46H38N2Os/(1-39)(2-42)(3-39)(4-39)(5-43)(6-41)(7-80)(8-47)(9-46)(10-83)(11-53)(12-51)(13-56)(14-55)(15-81)(16-49)(17-40)(18-40)(19-41)(20-58)(21-83)(22-63)(23-50)(24-62)(25-48)(26-61)(27-60)(28-45)(29-40)(30-82)(31-59)(32-52)(33-44)(34-41)(35-84)(36-84)(37-57)(38-54)(39-80)(40-75)(41-80)(42-43)(42-75)(43-64)(44-45)(44-64)(45-75)(46-47)(46-48)(47-67)(48-69)(49-55)(49-74)(50-56)(50-73)(51-72)(51-73)(52-57)(52-58)(53-56)(53-74)(54-59)(54-78)(55-69)(57-77)(58-68)(59-62)(60-63)(60-77)(61-78)(61-79)(62-76)(63-76)(64-80)(65-66)(65-73)(65-74)(66-67)(66-69)(67-72)(68-71)(68-79)(70-71)(70-76)(70-78)(71-77)(72-81)(79-82)(81-85)(82-86)(83-84)(83-85)(84-86)(85-87)(86-87)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PBMCs | 0.5 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MRC-5 | 0.8 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| A549 | 2.2 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR/CPR | 2.2 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR | 3.8 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Treatment with these complexes led to the activation of stress-related gene pathways, including unconventional endoplasmic reticulum stress, apoptotic signalling, and mitochondrial membrane depolariza...»
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