Info
| ID | 6472 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 7 |
| SMILES | C(=N\CC/N=C\c1cc2ccccc2c2ccccc12)\c1cc2ccccc2c2ccccc12.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C42H38N2Os/(1-39)(2-44)(3-39)(4-39)(5-42)(6-40)(7-76)(8-54)(9-47)(10-48)(11-55)(12-41)(13-53)(14-46)(15-61)(16-45)(17-41)(18-40)(19-52)(20-56)(21-58)(22-51)(23-41)(24-63)(25-57)(26-60)(27-59)(28-79)(29-79)(30-80)(31-77)(32-80)(33-50)(34-43)(35-40)(36-49)(37-78)(38-62)(39-76)(40-76)(41-71)(42-44)(42-64)(43-59)(43-64)(44-71)(45-61)(45-65)(46-53)(46-70)(47-54)(47-69)(48-54)(48-55)(49-68)(49-69)(50-56)(50-73)(51-57)(51-72)(52-56)(52-58)(53-61)(55-67)(57-63)(58-75)(59-71)(60-63)(60-66)(62-73)(62-74)(64-76)(65-68)(65-70)(66-72)(66-74)(67-69)(67-70)(68-77)(72-75)(73-75)(74-78)(77-81)(78-82)(79-80)(79-81)(80-82)(81-83)(82-83)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MRC-5 | 0.8 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| PBMCs | 1.3 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| A549 | 1.5 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR/CPR | 2 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR | 2.8 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Treatment with these complexes led to the activation of stress-related gene pathways, including unconventional endoplasmic reticulum stress, apoptotic signalling, and mitochondrial membrane depolariza...»