Info
| ID | 6471 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 6 |
| SMILES | C(=N\CC/N=C\c1c2ccccc2cc2ccccc12)\c1c2ccccc2cc2ccccc12.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C42H38N2Os/(1-40)(2-43)(3-40)(4-40)(5-42)(6-41)(7-41)(8-58)(9-45)(10-56)(11-46)(12-62)(13-47)(14-55)(15-48)(16-39)(17-76)(18-39)(19-57)(20-49)(21-51)(22-50)(23-52)(24-60)(25-54)(26-53)(27-39)(28-79)(29-77)(30-79)(31-80)(32-80)(33-63)(34-44)(35-41)(36-59)(37-78)(38-61)(39-72)(40-76)(41-76)(42-43)(42-72)(43-64)(44-58)(44-64)(45-55)(45-65)(46-49)(46-66)(47-51)(47-68)(48-57)(48-67)(49-55)(50-52)(50-69)(51-57)(52-60)(53-54)(53-63)(54-73)(56-66)(56-68)(58-72)(59-60)(59-71)(61-63)(61-74)(62-69)(62-73)(64-76)(65-66)(65-70)(67-68)(67-70)(69-71)(70-77)(71-75)(73-74)(74-75)(75-78)(77-81)(78-82)(79-80)(79-81)(80-82)(81-83)(82-83)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PBMCs | 0.2 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MRC-5 | 2.8 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR/CPR | 2.9 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| A549 | 3.4 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR | 5.2 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Treatment with these complexes led to the activation of stress-related gene pathways, including unconventional endoplasmic reticulum stress, apoptotic signalling, and mitochondrial membrane depolariza...»