Info
| ID | 6470 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2} |
| Abbreviation | 5 |
| SMILES | C(=N\CC/N=C\c1ccc2ccccc2c1)\c1ccc2ccccc2c1.Cc1ccc(C(C)C)cc1.[Cl-] |
TUCAN
C34H34N2Os/(1-35)(2-38)(3-35)(4-35)(5-39)(6-36)(7-64)(8-37)(9-47)(10-40)(11-43)(12-41)(13-37)(14-36)(15-37)(16-55)(17-44)(18-48)(19-49)(20-67)(21-52)(22-53)(23-65)(24-67)(25-68)(26-66)(27-45)(28-42)(29-50)(30-36)(31-51)(32-54)(33-46)(34-68)(35-64)(36-64)(37-56)(38-39)(38-56)(39-61)(40-47)(40-59)(41-59)(41-60)(42-45)(42-47)(43-48)(43-60)(44-62)(44-63)(45-57)(46-54)(46-58)(48-57)(49-50)(49-56)(50-61)(51-54)(51-55)(52-53)(52-58)(53-63)(55-62)(57-59)(58-62)(60-65)(61-64)(63-66)(65-69)(66-70)(67-68)(67-69)(68-70)(69-71)(70-71)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MOR/CPR | 0.5 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| PBMCs | 0.6 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| A549 | 1.2 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MRC-5 | 1.6 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
| MOR | 1.7 | — | 10.1016/j.ejmech.2025.117970 | 2025 |
🧬 Cell Death Types (1)
Apoptosis
high
«Treatment with these complexes led to the activation of stress-related gene pathways, including unconventional endoplasmic reticulum stress, apoptotic signalling, and mitochondrial membrane depolariza...»