Info
| ID | 6469 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 0 |
| Donor atoms | {"O": 1} |
| Abbreviation | OsCUR-2 |
| SMILES | COc1cc(/C=C/C(=O)/C=C([O-])/C=C/c2ccc(O)c(OC)c2)ccc1O.[Cl-].c1ccc(-c2ccccc2)cc1 |
TUCAN
C33ClO6Os/(1-2)(1-8)(2-22)(3-5)(3-30)(4-9)(4-22)(5-23)(6-17)(6-25)(7-12)(7-23)(8-9)(10-11)(10-24)(11-15)(12-28)(13-18)(13-31)(14-15)(14-16)(16-24)(17-32)(18-25)(19-23)(19-29)(20-30)(20-32)(21-25)(21-33)(22-24)(26-38)(27-39)(28-29)(28-34)(29-38)(30-36)(31-33)(31-35)(32-37)(33-39)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549cisR | 89 | 2.6 | 10.1021/acs.inorgchem.1c00241 | 2021 |
| A549 | 1.4e+02 | 5.8 | 10.1021/acs.inorgchem.1c00241 | 2021 |
| HLF | 1.8e+02 | 45 | 10.1021/acs.inorgchem.1c00241 | 2021 |
🧬 Cell Death Types (1)
Apoptosis
high
«Mitochondrial damage, apoptosis, ROS generation, DNA damage, angiogenesis inhibition, and colony formation were observed when A549 lung cancer cells were treated with OsCUR-2.»