Info
| ID | 6435 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 5} |
| Abbreviation | 4 |
| SMILES | Cc1ccc(C(C)C)cc1.Cc1ncc(CO)c(/C=N\NC2=Nc3ccccc3-c3[nH]c4ccc(Br)cc4c3C2)c1O.[Cl-] |
TUCAN
C34H34BrN5O2Os/(1-38)(2-58)(3-36)(4-36)(5-43)(6-59)(7-48)(8-38)(9-46)(10-50)(11-38)(12-60)(13-39)(14-47)(15-40)(16-66)(17-66)(18-41)(19-45)(20-50)(21-35)(22-35)(23-36)(24-42)(25-35)(26-37)(27-37)(28-37)(29-44)(30-49)(31-71)(32-70)(33-75)(34-74)(35-53)(36-58)(37-58)(38-62)(39-51)(39-68)(40-41)(40-52)(41-45)(42-43)(42-53)(43-54)(44-49)(44-54)(45-46)(46-63)(47-48)(47-64)(48-68)(49-53)(50-55)(50-65)(51-55)(51-64)(52-61)(52-63)(54-58)(55-61)(56-57)(56-60)(56-66)(57-59)(57-67)(59-73)(60-72)(61-70)(62-67)(62-72)(63-69)(64-70)(65-69)(65-71)(66-75)(67-74)(68-76)(71-73)(72-77)(73-77)(74-77)(75-77)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CH-1 | 0.63 | — | 10.1021/om700813c | 2007 |
| SW480 | 1 | — | 10.1021/om700813c | 2007 |
| A549 | 2 | — | 10.1021/om700813c | 2007 |
| CH-1 | 3.3 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| SW480 | 4.1 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| A549 | 10 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| NCI-N87 | 11 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| T47D | 12 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| LNCaP | 16 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 1 shows the strongest impact on cell viability, only 15% cells remain viable, whereas cells in early and late apoptosis amount to 72% in total.»