Info
| ID | 6434 |
| Metal | Os |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 4} |
| Abbreviation | 2 |
| SMILES | Cc1ccc(C(C)C)cc1.Oc1ccccc1/C=N\NC1=Nc2ccccc2-c2[nH]c3ccc(Br)cc3c2C1.[Cl-] |
TUCAN
C33H31BrN4OOs/(1-49)(2-40)(3-33)(4-57)(5-38)(6-50)(7-35)(8-46)(9-47)(10-45)(11-44)(12-37)(13-42)(14-43)(15-39)(16-58)(17-36)(18-50)(19-33)(20-32)(21-32)(22-33)(23-34)(24-32)(25-34)(26-34)(27-41)(28-48)(29-66)(30-65)(31-69)(32-54)(33-57)(34-57)(35-36)(35-37)(36-52)(37-43)(38-40)(38-54)(39-46)(39-63)(40-55)(41-48)(41-55)(42-44)(42-64)(43-59)(44-61)(45-51)(45-64)(46-49)(47-49)(47-56)(48-54)(50-53)(50-62)(51-53)(51-61)(52-59)(52-60)(53-60)(55-57)(56-58)(56-63)(58-68)(59-67)(60-65)(61-65)(62-66)(62-67)(63-69)(64-70)(66-68)(67-71)(68-71)(69-71)
Measurements (9)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| CH-1 | 0.75 | — | 10.1021/om700813c | 2007 |
| SW480 | 1.2 | — | 10.1021/om700813c | 2007 |
| CH-1 | 1.6 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| NCI-N87 | 1.6 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| SW480 | 1.7 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| A549 | 2.2 | — | 10.1021/om700813c | 2007 |
| T47D | 3.5 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| A549 | 4.6 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
| LNCaP | 5.3 | — | 10.1016/j.jinorgbio.2012.06.00... | 2012 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 1 shows the strongest impact on cell viability, only 15% cells remain viable, whereas cells in early and late apoptosis amount to 72% in total.»