Info
| ID | 64 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru5 |
| SMILES | CC#N.CC#N.CC#N.CC#N.Cc1c(C)c(C)c(C[n+]2[c-]n(-c3ccccn3)cc2)c(C)c1C |
TUCAN
C28N7Ru/(1-16)(2-19)(3-15)(4-18)(5-23)(6-17)(7-25)(8-14)(9-26)(10-11)(10-12)(11-24)(12-28)(13-15)(13-17)(13-21)(14-16)(14-18)(15-16)(17-18)(19-29)(20-22)(20-34)(21-34)(22-35)(23-30)(24-33)(25-31)(26-32)(27-34)(27-35)(28-33)(28-35)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 9 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 16 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 28 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 36 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | 56 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 82 | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»