Info
| ID | 6372 |
| Metal | Re |
| Oxidation state | 5 |
| Charge | 0 |
| Donor atoms | {"N": 2, "O": 2} |
| Abbreviation | 3 |
| SMILES | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C.[Cl-].[O-2].[O-]CC[O-] |
TUCAN
C18H20N2O2Re/(1-25)(2-21)(3-22)(4-37)(5-33)(6-22)(7-22)(8-24)(9-21)(10-34)(11-21)(12-26)(13-24)(14-37)(15-24)(16-23)(17-38)(18-38)(19-23)(20-23)(21-29)(22-30)(23-31)(24-32)(25-26)(25-27)(26-28)(27-30)(27-35)(28-32)(28-36)(29-30)(29-33)(31-32)(31-34)(33-39)(34-40)(35-36)(35-39)(36-40)(37-38)(37-41)(38-42)(39-43)(40-43)
Measurements (8)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 0.1 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| DU-145 | 0.1 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| DU-145cisR | 0.1 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| A2780cisR | 0.2 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| A2780 | 0.3 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| HeLa | 0.4 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| A549cisR | 0.4 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
| HeLa | 3.4 | — | 10.1021/acs.inorgchem.3c03110 | 2023 |
🧬 Cell Death Types (1)
Necroptosis
medium
«ER stress-mediated necrosis-mediated cancer cell death»