Info
| ID | 6354 |
| Metal | Re |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 4, "O": 1} |
| Abbreviation | DFX-Re3 |
| SMILES | O=C(NCCCc1ccncc1)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C56H41N7O6Re/(1-82)(2-43)(3-84)(4-46)(5-49)(6-66)(7-48)(8-42)(9-54)(10-64)(11-55)(12-44)(13-45)(14-59)(15-50)(16-56)(17-67)(18-47)(19-58)(20-86)(21-71)(22-86)(23-61)(24-62)(25-57)(26-70)(27-83)(28-60)(29-51)(30-52)(31-69)(32-68)(33-71)(34-70)(35-53)(36-63)(37-65)(38-85)(39-99)(40-109)(41-110)(42-44)(42-45)(43-44)(43-72)(45-58)(46-48)(46-75)(47-57)(47-60)(48-79)(49-66)(49-81)(50-51)(50-54)(51-52)(52-76)(53-55)(53-69)(54-95)(55-77)(56-78)(56-83)(57-62)(58-72)(59-74)(59-82)(60-63)(61-80)(61-84)(62-73)(63-73)(64-67)(64-81)(65-69)(65-96)(66-89)(67-89)(68-78)(68-85)(70-71)(70-78)(71-86)(72-74)(73-80)(74-75)(75-87)(76-90)(76-95)(77-91)(77-96)(79-80)(79-88)(81-97)(82-101)(83-102)(84-103)(85-102)(86-99)(87-88)(87-101)(88-103)(89-100)(90-98)(90-100)(91-98)(91-104)(92-105)(93-106)(94-107)(95-109)(96-110)(97-99)(97-108)(100-104)(101-111)(102-111)(103-111)(104-111)(110-111)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.4 | — | 10.1002/anie.202008624 | 2020 |
| MCF-7 | 13 | — | 10.1002/anie.202008624 | 2020 |
| MCF-10A | 19 | — | 10.1002/anie.202008624 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«DFX-Re3 induces immunogenic apoptotic cell death (abstract). Also: 'DFX-Re3 can induce caspase-dependent immunogenic apoptosis' (results). Annexin V/PI staining shows increase in apoptotic cells, casp...»
Immunogenic Cell Death
high
«DFX-Re3 induces immunogenic apoptotic cell death (abstract). Calreticulin exposure is shown (Figure 6B). Also: 'DFX-Re3 can induce caspase-dependent immunogenic apoptosis' (results).»