Info
| ID | 6353 |
| Metal | Re |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 4, "O": 1} |
| Abbreviation | DFX-Re2 |
| SMILES | Cc1ccnc2c1ccc1c(C)ccnc12.O=C(NCCCc1ccncc1)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C46H37N7O6Re/(1-58)(2-40)(3-68)(4-59)(5-71)(6-43)(7-38)(8-44)(9-58)(10-59)(11-41)(12-72)(13-72)(14-52)(15-46)(16-51)(17-53)(18-42)(19-45)(20-57)(21-47)(22-69)(23-55)(24-38)(25-38)(26-39)(27-39)(28-54)(29-39)(30-56)(31-70)(32-48)(33-49)(34-50)(35-85)(36-95)(37-96)(38-60)(39-61)(40-51)(40-73)(41-46)(41-81)(42-47)(42-82)(43-60)(43-69)(44-45)(44-46)(45-63)(47-48)(48-49)(49-64)(50-53)(50-73)(51-62)(52-65)(52-68)(53-62)(54-56)(54-66)(55-61)(55-70)(56-67)(57-65)(57-71)(58-59)(58-65)(59-72)(60-66)(61-67)(62-83)(63-77)(63-81)(64-76)(64-82)(66-74)(67-75)(68-87)(69-88)(70-89)(71-87)(72-85)(73-86)(74-75)(74-88)(75-89)(76-84)(76-90)(77-84)(77-86)(78-91)(79-92)(80-94)(81-95)(82-96)(83-85)(83-93)(86-90)(87-97)(88-97)(89-97)(90-97)(96-97)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MDA-MB-231 | 0.7 | — | 10.1002/anie.202008624 | 2020 |
| MCF-7 | 15 | — | 10.1002/anie.202008624 | 2020 |
| MCF-10A | 21 | — | 10.1002/anie.202008624 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«DFX-Re3 induces immunogenic apoptotic cell death (abstract). Also: 'DFX-Re3 can induce caspase-dependent immunogenic apoptosis' (results). Annexin V/PI staining shows increase in apoptotic cells, casp...»
Immunogenic Cell Death
high
«DFX-Re3 induces immunogenic apoptotic cell death (abstract). Calreticulin exposure is shown (Figure 6B). Also: 'DFX-Re3 can induce caspase-dependent immunogenic apoptosis' (results).»