Info
| ID | 6352 |
| Metal | Re |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 4, "O": 1} |
| Abbreviation | DFX-Re1 |
| SMILES | O=C(NCCCc1ccncc1)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C44H33N7O6Re/(1-37)(2-42)(3-41)(4-35)(5-52)(6-47)(7-38)(8-53)(9-45)(10-62)(11-54)(12-43)(13-63)(14-48)(15-55)(16-44)(17-34)(18-46)(19-54)(20-36)(21-39)(22-50)(23-64)(24-51)(25-49)(26-55)(27-66)(28-40)(29-66)(30-65)(31-79)(32-90)(33-89)(34-37)(34-62)(35-38)(35-61)(36-39)(36-56)(37-56)(38-67)(39-59)(40-41)(40-49)(41-57)(42-43)(42-76)(43-44)(44-45)(45-58)(46-52)(46-67)(47-60)(47-64)(48-49)(48-75)(50-51)(50-59)(51-63)(52-61)(53-60)(53-65)(54-55)(54-60)(55-66)(56-68)(57-71)(57-75)(58-70)(58-76)(59-69)(61-77)(62-81)(63-82)(64-83)(65-83)(66-79)(67-80)(68-69)(68-81)(69-82)(70-78)(70-84)(71-78)(71-80)(72-85)(73-87)(74-88)(75-89)(76-90)(77-79)(77-86)(80-84)(81-91)(82-91)(83-91)(84-91)(90-91)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 16 | — | 10.1002/anie.202008624 | 2020 |
| MDA-MB-231 | 25 | — | 10.1002/anie.202008624 | 2020 |
| MCF-10A | 29 | — | 10.1002/anie.202008624 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«DFX-Re3 induces immunogenic apoptotic cell death (abstract). Also: 'DFX-Re3 can induce caspase-dependent immunogenic apoptosis' (results). Annexin V/PI staining shows increase in apoptotic cells, casp...»
Immunogenic Cell Death
high
«DFX-Re3 induces immunogenic apoptotic cell death (abstract). Calreticulin exposure is shown (Figure 6B). Also: 'DFX-Re3 can induce caspase-dependent immunogenic apoptosis' (results).»