Info
| ID | 6335 |
| Metal | Re |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | Re-2 |
| SMILES | OCc1ccncc1.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C33H23N3O4Re/(1-26)(2-27)(3-25)(4-29)(5-38)(6-24)(7-31)(8-30)(9-47)(10-37)(11-33)(12-32)(13-36)(14-48)(15-28)(16-34)(17-35)(18-56)(19-49)(20-39)(21-56)(22-50)(23-63)(24-26)(24-40)(25-26)(25-27)(27-31)(28-29)(28-32)(29-34)(30-37)(30-42)(31-40)(32-45)(33-41)(33-47)(34-36)(35-44)(35-48)(36-45)(37-43)(38-46)(38-49)(39-46)(39-50)(40-41)(41-42)(42-51)(43-44)(43-52)(44-45)(46-56)(47-57)(48-58)(49-59)(50-59)(51-52)(51-57)(52-58)(53-60)(54-61)(55-62)(56-63)(57-64)(58-64)(59-64)(63-64)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 4.8 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| A549 | 5.1 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| HepG2 | 5.5 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| A549cisR | 6.7 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| LO2 | 8.8 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«Mechanism studies show that Re-ART-1 and Re-ART-2 ... can induce both apoptosis and ferroptosis in HeLa cells through mitochondrial damage, caspase cascade»
Ferroptosis
high
«Mechanism studies show that Re-ART-1 and Re-ART-2 ... can induce both apoptosis and ferroptosis in HeLa cells through ... glutathione (GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation and ...»