Info
| ID | 6333 |
| Metal | Re |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | Re-ART-2 |
| SMILES | C[C@@H]1[C@@H](OC(=O)CCC(=O)OCc2ccncc2)O[C@H]2O[C@]3(C)CC[C@@H]4[C@@H](C)CC[C@@H]1[C@]24OO3.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc(-c2ccnc3c2ccc2c(-c4ccccc4)ccnc23)cc1 |
TUCAN
C52H49N3O11Re/(1-52)(2-56)(3-54)(4-63)(5-55)(6-86)(7-59)(8-82)(9-60)(10-65)(11-66)(12-52)(13-100)(14-61)(15-58)(16-72)(17-67)(18-50)(19-88)(20-68)(21-71)(22-71)(23-89)(24-50)(25-50)(26-99)(27-83)(28-72)(29-62)(30-53)(31-57)(32-70)(33-85)(34-51)(35-73)(36-87)(37-74)(38-74)(39-51)(40-69)(41-52)(42-70)(43-84)(44-73)(45-64)(46-51)(47-69)(48-95)(49-95)(50-83)(51-84)(52-101)(53-57)(53-76)(54-55)(54-79)(55-56)(56-60)(57-77)(58-75)(58-86)(59-60)(59-79)(61-65)(61-80)(62-66)(62-80)(63-65)(63-66)(64-78)(64-87)(67-81)(67-88)(68-81)(68-89)(69-70)(69-85)(70-101)(71-72)(71-98)(72-97)(73-74)(73-82)(74-84)(75-76)(75-79)(76-90)(77-78)(77-91)(78-80)(81-95)(82-83)(82-96)(83-99)(84-85)(85-96)(86-102)(87-103)(88-104)(89-104)(90-91)(90-102)(91-103)(92-105)(93-106)(94-107)(95-114)(96-100)(96-112)(97-108)(97-113)(98-109)(98-114)(99-113)(99-115)(100-110)(100-115)(101-110)(101-111)(102-116)(103-116)(104-116)(111-112)(113-116)(114-116)(115-116)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 0.8 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| HepG2 | 1 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| A549 | 1.1 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| A549cisR | 1.5 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| LO2 | 8.6 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«Mechanism studies show that Re-ART-1 and Re-ART-2 ... can induce both apoptosis and ferroptosis in HeLa cells through mitochondrial damage, caspase cascade»
Ferroptosis
high
«Mechanism studies show that Re-ART-1 and Re-ART-2 ... can induce both apoptosis and ferroptosis in HeLa cells through ... glutathione (GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation and ...»