Info
| ID | 6332 |
| Metal | Re |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | Re-ART-1 |
| SMILES | C[C@@H]1[C@@H](OC(=O)CCC(=O)OCc2ccncc2)O[C@H]2O[C@]3(C)CC[C@@H]4[C@@H](C)CC[C@@H]1[C@]24OO3.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C40H41N3O11Re/(1-55)(2-58)(3-49)(4-66)(5-53)(6-53)(7-50)(8-46)(9-42)(10-43)(11-64)(12-58)(13-43)(14-68)(15-51)(16-75)(17-63)(18-54)(19-57)(20-42)(21-55)(22-43)(23-54)(24-57)(25-45)(26-47)(27-56)(28-79)(29-65)(30-44)(31-56)(32-80)(33-42)(34-67)(35-48)(36-75)(37-62)(38-69)(39-52)(40-44)(41-44)(42-62)(43-81)(44-65)(45-47)(45-59)(46-49)(46-59)(47-60)(48-61)(48-67)(49-66)(50-51)(50-68)(51-60)(52-61)(52-69)(53-54)(53-63)(54-81)(55-56)(55-78)(56-77)(57-58)(57-62)(58-64)(59-70)(60-71)(61-75)(62-63)(63-76)(64-65)(64-76)(65-79)(66-82)(67-83)(68-84)(69-83)(70-71)(70-82)(71-84)(72-86)(73-87)(74-88)(75-95)(76-80)(76-91)(77-85)(77-93)(78-89)(78-95)(79-93)(79-94)(80-90)(80-94)(81-90)(81-92)(82-96)(83-96)(84-96)(91-92)(93-96)(94-96)(95-96)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 5.2 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| HepG2 | 11 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| A549 | 13 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| A549cisR | 22 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
| LO2 | 22 | — | 10.1016/j.jinorgbio.2021.11153... | 2021 |
🧬 Cell Death Types (2)
Apoptosis
high
«Mechanism studies show that Re-ART-1 and Re-ART-2 ... can induce both apoptosis and ferroptosis in HeLa cells through mitochondrial damage, caspase cascade»
Ferroptosis
high
«Mechanism studies show that Re-ART-1 and Re-ART-2 ... can induce both apoptosis and ferroptosis in HeLa cells through ... glutathione (GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation and ...»