Info
| ID | 63 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru4 |
| SMILES | CC#N.CC#N.[c-]1n(-c2ccccn2)cc[n+]1Cc1ccccc1.c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C31H27N7Ru/(1-32)(2-28)(3-28)(4-28)(5-51)(6-33)(7-35)(8-37)(9-43)(10-30)(11-52)(12-41)(13-50)(14-38)(15-42)(16-53)(17-29)(18-29)(19-29)(20-39)(21-36)(22-40)(23-54)(24-49)(25-54)(26-31)(27-34)(28-47)(29-48)(30-31)(30-37)(31-39)(32-35)(32-44)(33-41)(33-44)(34-36)(34-46)(35-51)(36-52)(37-45)(38-42)(38-43)(39-40)(40-45)(41-46)(42-58)(43-53)(44-55)(45-54)(46-56)(47-59)(48-60)(49-50)(49-62)(50-61)(51-64)(52-65)(53-63)(54-62)(55-56)(55-64)(56-65)(57-61)(57-62)(58-61)(58-63)(63-66)(64-66)(65-66)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 11 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 33 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 35 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 40 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 98 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | — | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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