Info
| ID | 6287 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | [Re(CO)3(N(SO2)(1-nap)dien)] |
| SMILES | NCCNCC[N-]S(=O)(=O)c1cccc2ccccc12.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C17H18N3O5ReS/(1-20)(2-29)(3-29)(4-22)(5-31)(6-31)(7-19)(8-21)(9-28)(10-30)(11-28)(12-30)(13-25)(14-23)(15-24)(16-36)(17-36)(18-37)(19-22)(19-26)(20-21)(20-22)(21-27)(23-24)(23-25)(24-35)(25-27)(26-27)(26-35)(28-30)(28-37)(29-31)(29-37)(30-36)(31-38)(32-39)(33-40)(34-41)(35-44)(38-44)(38-45)(42-44)(43-44)(44-45)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| NCI-H292 | 9.9 | — | 10.1016/j.poly.2020.114652 | 2020 |
| NCI-H292 | 17 | — | 10.1016/j.poly.2020.114652 | 2020 |
| NCI-H292 | 19 | — | 10.1016/j.poly.2020.114652 | 2020 |
| MRC-5 | 31 | — | 10.1016/j.poly.2020.114652 | 2020 |
| MRC-5 | 55 | — | 10.1016/j.poly.2020.114652 | 2020 |
| MRC-5 | 95 | — | 10.1016/j.poly.2020.114652 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«NCI-H292 cells treated with C1 indicated clear morphological changes, such as cell shrinkage, reduction in cell volume and irregular cell shapes, which are indicative of apoptotic cell death.»