Info
| ID | 6268 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"O": 3, "N": 4} |
| Abbreviation | ReL |
| SMILES | [C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-].c1ccc2c(-c3ccc4nc5c6cccnc6c6ncccc6c5nc4c3)cccc2c1 |
TUCAN
C31H16N4O3Re/(1-37)(2-21)(3-38)(4-19)(5-25)(6-23)(7-27)(8-18)(9-24)(10-17)(11-29)(12-30)(13-22)(14-28)(15-20)(16-26)(17-35)(17-41)(18-23)(18-36)(19-23)(19-33)(20-22)(20-32)(21-26)(21-33)(22-37)(24-25)(24-31)(25-38)(26-30)(27-29)(27-35)(28-30)(28-34)(29-44)(31-39)(31-40)(32-42)(32-43)(33-34)(34-36)(35-36)(37-48)(38-50)(39-42)(39-51)(40-43)(40-50)(41-44)(41-49)(42-49)(43-48)(44-51)(45-52)(46-53)(47-54)(50-55)(51-55)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116CD44+ | 7.2 | — | 10.1021/acsabm.2c00556 | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«The level of BAX and Bcl-2 was further quantified by qRT-PCR. The expression of proapoptotic BAX showed increased expression in the complex IrL-treated cell compared to the control, indicating the pot...»
Autophagy
high
«Upon further validation, complex IrL was developed as an inhibitor of autophagy for the eradication of cancer stem cells.»