Info
| ID | 6268 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"O": 3, "N": 4} |
| Abbreviation | ReL |
| SMILES | [C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-].c1ccc2c(-c3ccc4nc5c6cccnc6c6ncccc6c5nc4c3)cccc2c1 |
TUCAN
C31H16N4O3Re/(1-37)(2-21)(3-38)(4-19)(5-25)(6-23)(7-27)(8-18)(9-24)(10-17)(11-29)(12-30)(13-22)(14-28)(15-20)(16-26)(17-35)(17-41)(18-23)(18-36)(19-23)(19-33)(20-22)(20-32)(21-26)(21-33)(22-37)(24-25)(24-31)(25-38)(26-30)(27-29)(27-35)(28-30)(28-34)(29-44)(31-39)(31-40)(32-42)(32-43)(33-34)(34-36)(35-36)(37-48)(38-50)(39-42)(39-51)(40-43)(40-50)(41-44)(41-49)(42-49)(43-48)(44-51)(45-52)(46-53)(47-54)(50-55)(51-55)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HCT-116CD44+ | 7.2 | — | 10.1021/acsabm.2c00556 | 2023 |
🧬 Cell Death Types (2)
Apoptosis
high
«The level of BAX and Bcl-2 was further quantified by qRT-PCR. The expression of proapoptotic BAX showed increased expression in the complex IrL-treated cell compared to the control, indicating the pot...»
Autophagy
high
«Upon further validation, complex IrL was developed as an inhibitor of autophagy for the eradication of cancer stem cells.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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