Info
| ID | 62 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | Ru3 |
| SMILES | CC#N.CC#N.Cc1ccc(-c2ccc(C)cn2)nc1.[c-]1n(-c2ccccn2)cc[n+]1Cc1ccccc1 |
TUCAN
C31H31N7Ru/(1-33)(2-58)(3-32)(4-32)(5-32)(6-33)(7-58)(8-45)(9-53)(10-38)(11-44)(12-40)(13-39)(14-43)(15-34)(16-34)(17-34)(18-33)(19-35)(20-56)(21-41)(22-54)(23-36)(24-37)(25-42)(26-55)(27-35)(28-57)(29-35)(30-47)(31-46)(32-51)(33-49)(34-52)(35-50)(36-39)(36-48)(37-41)(37-48)(38-42)(38-53)(39-40)(40-41)(42-43)(43-62)(44-45)(44-59)(45-49)(46-47)(46-50)(47-60)(48-58)(49-55)(50-57)(51-63)(52-64)(53-67)(54-56)(54-65)(55-68)(56-66)(57-69)(58-65)(59-60)(59-68)(60-69)(61-65)(61-66)(62-66)(62-67)(67-70)(68-70)(69-70)
Measurements (6)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| B16-F10 | 19 | — | 10.1002/chem.202002970 | 2020 |
| A2780 | 62 | — | 10.1002/chem.202002970 | 2020 |
| A549 | 80 | — | 10.1002/chem.202002970 | 2020 |
| HuH-7 | 84 | — | 10.1002/chem.202002970 | 2020 |
| A549cisR | 91 | — | 10.1002/chem.202002970 | 2020 |
| HUVEC | — | — | 10.1002/chem.202002970 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«Upregulation of apoptosis-related proteins (e.g., c-PARP, c-Caspase 3 and c-Caspase 9) confirmed that the cell apoptosis could be efficiently induced by Ru8 via the classical apoptotic pathway.»