Info
| ID | 6197 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 0 |
| Donor atoms | {"N": 4, "O": 3} |
| Abbreviation | 3b |
| SMILES | Brc1ccc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+].[Cl-] |
TUCAN
C22H11BrN4O3Re/(1-24)(2-18)(3-17)(4-13)(5-14)(6-16)(7-19)(8-12)(9-15)(10-23)(11-35)(12-15)(12-20)(13-14)(13-33)(14-22)(15-23)(16-19)(16-22)(17-18)(17-21)(18-24)(19-33)(20-25)(20-26)(21-27)(21-28)(22-29)(23-34)(24-36)(25-27)(25-34)(26-28)(26-35)(27-36)(28-37)(29-35)(29-37)(30-38)(31-39)(32-40)(33-41)(36-42)(37-42)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 29 | — | 10.1039/d3dt04383e | 2024 |
| HeLa | 63 | — | 10.1039/d3dt04383e | 2024 |
| MDA-MB-231 | 68 | 25 | 10.1002/chem.202401720 | 2024 |
| HEK293 | 85 | — | 10.1039/d3dt04383e | 2024 |
| MRC-5 | 98 | 97 | 10.1002/chem.202401720 | 2024 |
🧬 Cell Death Types (1)
Apoptosis
high
«Complex 3c also showed competency to induce apoptosis in MCF-7 cells through G2/M phase cell-cycle arrest in association with the generation of ample reactive oxygen species (ROS), eventually leading ...»