Info
| ID | 619 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 1 |
| Donor atoms | {"N": 2, "P": 1} |
| Abbreviation | PMC79 |
| SMILES | OCc1ccnc(-c2cc(CO)ccn2)c1.c1cc[cH-]c1.c1ccc(P(c2ccccc2)c2ccccc2)cc1 |
TUCAN
C35H32N2O2PRu/(1-34)(2-33)(3-36)(4-46)(5-35)(6-44)(7-51)(8-48)(9-52)(10-45)(11-49)(12-56)(13-40)(14-60)(15-63)(16-37)(17-38)(18-39)(19-41)(20-47)(21-50)(22-53)(23-54)(24-42)(25-64)(26-55)(27-59)(28-43)(29-63)(30-64)(31-71)(32-70)(33-34)(33-36)(34-65)(35-36)(35-46)(37-38)(37-39)(38-41)(39-42)(40-57)(40-62)(41-42)(43-57)(43-59)(44-48)(44-51)(45-48)(45-52)(46-65)(47-49)(47-53)(49-50)(50-54)(51-66)(52-66)(53-67)(54-67)(55-58)(55-61)(56-58)(56-60)(57-63)(58-64)(59-69)(60-68)(61-62)(61-68)(62-69)(63-71)(64-70)(65-72)(66-72)(67-72)(68-73)(69-73)(71-73)
Measurements (11)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| MCF-7 | 0.3 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| MDA-MB-231 | 2.1 | — | 10.1016/j.ejmech.2019.02.061 | 2019 |
| MDA-MB-231 | 2.2 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| RKO | 3 | — | 10.3390/pharmaceutics15061731 | 2023 |
| A2780 | 3.9 | — | 10.1016/j.ejmech.2019.02.061 | 2019 |
| MCF-7 | 4.6 | — | 10.1016/j.ejmech.2018.12.022 | 2019 |
| MCF-7 | 5.9 | — | 10.1016/j.ejmech.2019.02.061 | 2019 |
| MDA-MB-231 | 14 | — | 10.1016/j.ejmech.2018.12.022 | 2019 |
| V79 | 25 | — | 10.1016/j.jinorgbio.2023.11243... | 2024 |
| SW480 | 40 | — | 10.3390/pharmaceutics15061731 | 2023 |
| NCM460 | 44 | — | 10.3390/pharmaceutics15061731 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«The conjugate PMC3 induced apoptosis at low concentrations comparing to cisplatin and could overcame the platinum resistance of A2780cis cancer cells.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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