Info
| ID | 6174 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "Cl": 1, "O": 3} |
| Abbreviation | TRIP-1e |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.[C-]#[N+]c1ccc(Cl)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C24H16ClN3O3Re/(1-17)(2-23)(3-22)(4-24)(5-17)(6-26)(7-25)(8-17)(9-20)(10-18)(11-18)(12-19)(13-18)(14-27)(15-21)(16-28)(17-32)(18-33)(19-20)(19-40)(20-34)(21-28)(21-40)(22-25)(22-29)(23-24)(23-29)(24-32)(25-30)(26-27)(26-30)(27-33)(28-34)(29-35)(30-36)(31-41)(32-42)(33-43)(34-41)(35-36)(35-42)(36-43)(37-44)(38-45)(39-46)(40-47)(41-48)(42-48)(43-48)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A2780 | 0.9 | — | 10.1002/anie.202004883 | 2020 |
| A2780TR | 1.7 | — | 10.1002/anie.202004883 | 2020 |
| HeLa | 9.3 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»