Info
| ID | 6173 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 4} |
| Abbreviation | TRIP-1d |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.[C-]#[N+]c1ccc(OC)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C25H19N3O4Re/(1-26)(2-20)(3-27)(4-25)(5-28)(6-29)(7-20)(8-30)(9-23)(10-24)(11-22)(12-43)(13-20)(14-21)(15-21)(16-21)(17-43)(18-43)(19-31)(20-35)(21-36)(22-23)(22-44)(23-37)(24-31)(24-37)(25-28)(25-32)(26-27)(26-32)(27-35)(28-33)(29-30)(29-33)(30-36)(31-44)(32-38)(33-39)(34-45)(35-46)(36-47)(37-45)(38-39)(38-46)(39-47)(40-48)(41-49)(42-50)(43-51)(44-51)(45-52)(46-52)(47-52)(51-52)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 5 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»