Info
| ID | 6172 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-1c |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.[C-]#[N+]c1cc(C)cc(C)c1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C26H21N3O3Re/(1-28)(2-22)(3-23)(4-23)(5-23)(6-22)(7-29)(8-31)(9-22)(10-25)(11-25)(12-26)(13-24)(14-30)(15-32)(16-33)(17-25)(18-34)(19-27)(20-24)(21-24)(22-36)(23-41)(24-37)(25-44)(26-36)(26-40)(27-37)(27-40)(28-29)(28-41)(29-35)(30-32)(30-35)(31-36)(31-37)(32-38)(33-34)(33-38)(34-44)(35-42)(38-43)(39-50)(40-50)(41-48)(42-43)(42-48)(43-49)(44-49)(45-51)(46-52)(47-53)(48-54)(49-54)(50-54)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 6.8 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»