Info
| ID | 6171 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-1b |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.[C-]#[N+]c1c(C)cccc1C.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C26H21N3O3Re/(1-27)(2-22)(3-22)(4-28)(5-31)(6-26)(7-33)(8-24)(9-24)(10-24)(11-34)(12-22)(13-30)(14-29)(15-25)(16-25)(17-25)(18-32)(19-23)(20-23)(21-23)(22-35)(23-36)(24-41)(25-44)(26-31)(26-35)(27-28)(27-41)(28-37)(29-32)(29-37)(30-31)(30-36)(32-38)(33-34)(33-38)(34-44)(35-40)(36-40)(37-42)(38-43)(39-48)(40-48)(41-49)(42-43)(42-49)(43-50)(44-50)(45-51)(46-52)(47-53)(48-54)(49-54)(50-54)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.8 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»