Info
| ID | 6170 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-7a |
| SMILES | CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.[C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C29H31N3O3Re/(1-33)(2-33)(3-33)(4-43)(5-40)(6-32)(7-32)(8-34)(9-34)(10-34)(11-35)(12-35)(13-35)(14-53)(15-36)(16-36)(17-45)(18-36)(19-39)(20-42)(21-37)(22-44)(23-37)(24-54)(25-37)(26-38)(27-38)(28-38)(29-41)(30-46)(31-32)(32-47)(33-50)(34-50)(35-50)(36-51)(37-51)(38-51)(39-40)(39-47)(40-57)(41-46)(41-57)(42-48)(42-55)(43-48)(43-53)(44-49)(44-56)(45-49)(45-54)(46-47)(48-50)(49-51)(52-61)(53-62)(54-63)(55-56)(55-62)(56-63)(57-61)(58-64)(59-65)(60-66)(61-67)(62-67)(63-67)
Measurements (3)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.2 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
| A2780 | 2.3 | — | 10.1002/anie.202004883 | 2020 |
| A2780TR | 7.3 | — | 10.1002/anie.202004883 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»