Info
| ID | 617 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 6} |
| Abbreviation | KS-Ru |
| SMILES | N=C(N)NCCC[C@H](NC(=O)c1cc2c([nH]c3ccccc32)c(-c2ccc3ccccc3n2)n1)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C56H54N14O9Ru/(1-56)(2-76)(3-77)(4-59)(5-62)(6-104)(7-65)(8-84)(9-75)(10-79)(11-88)(12-104)(13-66)(14-79)(15-88)(16-80)(17-74)(18-85)(19-57)(20-60)(21-100)(22-55)(23-58)(24-86)(25-61)(26-69)(27-72)(28-70)(29-71)(30-87)(31-80)(32-64)(33-63)(34-89)(35-73)(36-78)(37-89)(38-67)(39-68)(40-102)(41-101)(42-78)(43-113)(44-118)(45-111)(46-119)(47-111)(48-117)(49-114)(50-115)(51-116)(52-131)(53-133)(54-132)(55-57)(55-90)(56-57)(56-84)(58-60)(58-91)(59-60)(59-85)(61-70)(61-95)(62-70)(62-86)(63-64)(63-92)(64-81)(65-66)(65-76)(66-81)(67-68)(67-82)(68-74)(69-71)(69-96)(71-72)(72-87)(73-83)(73-99)(74-75)(75-94)(76-77)(77-98)(78-101)(78-109)(79-80)(79-102)(80-89)(81-98)(82-83)(82-94)(83-97)(84-120)(85-121)(86-122)(87-123)(88-108)(88-117)(89-116)(90-91)(90-120)(91-121)(92-93)(92-124)(93-97)(93-112)(94-114)(95-96)(95-122)(96-123)(97-114)(98-124)(99-106)(99-112)(100-104)(100-110)(100-113)(101-107)(101-118)(102-105)(102-115)(103-111)(103-116)(103-119)(104-133)(105-117)(105-127)(106-115)(106-126)(107-113)(107-128)(108-118)(108-129)(109-125)(109-132)(110-130)(110-131)(119-134)(120-134)(121-134)(122-134)(123-134)(124-134)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| A549 | 33 | — | 10.1002/smll.202310636 | 2024 |
| MCF-7 | 34 | — | 10.1002/smll.202310636 | 2024 |
| HepG2 | 48 | — | 10.1002/smll.202310636 | 2024 |
| B16-F10 | 85 | — | 10.1002/smll.202310636 | 2024 |
| HL-7702 | — | — | 10.1002/smll.202310636 | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«Within the lysosomes, KS-Ru self-assembled into nanoflowers, leading to lysosomal swelling and apoptosis.»
Immunogenic Cell Death
high
«Several DNA-damaging antitumor agents, including ruthenium complexes, induce immunogenic cell death (ICD). ... KS-Ru translocates to the nucleus, causing DNA damage and inducing ICD.»