Info
| ID | 6169 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-6a |
| SMILES | FC(F)(F)c1ccnc(-c2cc(C(F)(F)F)ccn2)c1.[C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C23H13F6N3O3Re/(1-16)(2-27)(3-14)(4-18)(5-19)(6-14)(7-28)(8-20)(9-15)(10-21)(11-17)(12-22)(13-14)(14-25)(15-16)(15-25)(16-30)(17-22)(17-30)(18-23)(18-27)(19-24)(19-28)(20-23)(20-29)(21-24)(21-31)(22-25)(23-35)(24-36)(26-37)(27-38)(28-39)(29-31)(29-38)(30-37)(31-39)(32-40)(33-41)(34-42)(35-43)(35-44)(35-45)(36-46)(36-47)(36-48)(37-49)(38-49)(39-49)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 53 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»
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