Info
| ID | 6168 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-5a |
| SMILES | COc1ccnc(-c2cc(OC)ccn2)c1.[C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C23H19N3O5Re/(1-20)(2-20)(3-23)(4-31)(5-20)(6-25)(7-39)(8-21)(9-22)(10-39)(11-39)(12-40)(13-28)(14-40)(15-24)(16-26)(17-32)(18-40)(19-27)(20-29)(21-25)(21-33)(22-34)(22-41)(23-31)(23-41)(24-35)(24-42)(25-29)(26-32)(26-42)(27-28)(27-33)(28-29)(30-44)(31-43)(32-45)(33-44)(34-35)(34-43)(35-45)(36-46)(37-47)(38-48)(39-49)(40-50)(41-49)(42-50)(43-51)(44-51)(45-51)(49-51)(50-51)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 8.4 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»