Info
| ID | 6167 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-4a |
| SMILES | Cc1ccnc(-c2cc(C)ccn2)c1.[C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C23H19N3O3Re/(1-21)(2-25)(3-23)(4-20)(5-20)(6-21)(7-35)(8-36)(9-21)(10-28)(11-22)(12-26)(13-29)(14-30)(15-22)(16-22)(17-24)(18-27)(19-20)(20-31)(21-32)(22-33)(23-26)(23-37)(24-27)(24-37)(25-32)(25-38)(26-31)(27-31)(28-32)(28-35)(29-33)(29-36)(30-33)(30-39)(34-45)(35-43)(36-44)(37-45)(38-39)(38-43)(39-44)(40-46)(41-47)(42-48)(43-49)(44-49)(45-49)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 7.6 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»