Info
| ID | 6166 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-3a |
| SMILES | [C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc(-c2ccccn2)nc1 |
TUCAN
C21H15N3O3Re/(1-17)(2-23)(3-24)(4-25)(5-18)(6-29)(7-19)(8-30)(9-22)(10-20)(11-21)(12-16)(13-16)(14-16)(15-26)(16-27)(17-18)(17-31)(18-19)(19-29)(20-21)(20-33)(21-22)(22-30)(23-24)(23-32)(24-27)(25-26)(25-32)(26-27)(28-37)(29-38)(30-39)(31-33)(31-38)(32-37)(33-39)(34-40)(35-41)(36-42)(37-43)(38-43)(39-43)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 28 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»