Info
| ID | 6165 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-2a |
| SMILES | [C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1cnc2c(c1)ccc1cccnc12 |
TUCAN
C23H15N3O3Re/(1-21)(2-20)(3-16)(4-16)(5-31)(6-32)(7-18)(8-24)(9-23)(10-17)(11-22)(12-19)(13-26)(14-25)(15-16)(16-29)(17-22)(17-27)(18-21)(18-31)(19-20)(19-29)(20-34)(21-27)(22-28)(23-24)(23-28)(24-32)(25-26)(25-34)(26-29)(27-33)(28-35)(30-40)(31-39)(32-41)(33-35)(33-39)(34-40)(35-41)(36-42)(37-43)(38-44)(39-45)(40-45)(41-45)
Measurements (1)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 5.8 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
🧬 Cell Death Types (1)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»