Info
| ID | 6164 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 3, "O": 3} |
| Abbreviation | TRIP-1a |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.[C-]#[N+]c1ccc(C)cc1.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C25H19N3O3Re/(1-25)(2-23)(3-21)(4-21)(5-31)(6-21)(7-24)(8-20)(9-20)(10-22)(11-28)(12-27)(13-32)(14-26)(15-22)(16-22)(17-29)(18-30)(19-20)(20-33)(21-40)(22-41)(23-28)(23-39)(24-31)(24-34)(25-26)(25-34)(26-35)(27-32)(27-35)(28-33)(29-30)(29-39)(30-33)(31-40)(32-41)(34-37)(35-38)(36-45)(37-38)(37-46)(38-47)(39-45)(40-46)(41-47)(42-48)(43-49)(44-50)(45-51)(46-51)(47-51)
Measurements (13)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HeLa | 1.4 | — | 10.1021/acs.inorgchem.0c01442 | 2020 |
| HeLa | 1.4 | — | 10.1002/chem.201902223 | 2019 |
| A549 | 1.4 | — | 10.1002/chem.201902223 | 2019 |
| A2780 | 1.5 | — | 10.1002/anie.202004883 | 2020 |
| A2780 | 1.7 | — | 10.1002/chem.201902223 | 2019 |
| A2780-CP70 | 1.9 | — | 10.1002/chem.201902223 | 2019 |
| HEK293 | 1.9 | — | 10.1002/chem.201902223 | 2019 |
| A375P | 4.8 | — | 10.3389/fchem.2022.850638 | 2022 |
| CaSki | 5 | — | 10.3389/fchem.2022.850638 | 2022 |
| HeLa | 5.3 | — | 10.3389/fchem.2022.850638 | 2022 |
| A2780TR | 13 | — | 10.1002/anie.202004883 | 2020 |
| HEK293T | — | — | 10.3389/fchem.2022.850638 | 2022 |
| C8-D1A | — | — | 10.3389/fchem.2022.850638 | 2022 |
🧬 Cell Death Types (2)
Apoptosis
high
«the parent complex in this series, TRIP-1a, increases the level of misfolded proteins in cells, which triggers ER stress. Subsequently, activation of the UPR and apoptosis ultimately lead to cell deat...»
Autophagy
high
«After 24 h, a large increase in LC3II expression relative to LC3I was observed in cells treated with TRIP... Based on these results, it is clear that TRIP induces both autophagy and apoptosis.»