Info
| ID | 6160 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 2, "O": 3} |
| Abbreviation | 13 |
| SMILES | Cc1ccc2ccc3ccc(C)nc3c2n1.O.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C17H12N2O3Re/(1-16)(2-17)(3-13)(4-15)(5-19)(6-13)(7-13)(8-18)(9-20)(10-14)(11-14)(12-14)(13-25)(14-26)(15-18)(15-21)(16-17)(16-21)(17-25)(18-22)(19-20)(19-22)(20-26)(21-23)(22-24)(23-24)(23-30)(24-31)(25-30)(26-31)(27-32)(28-33)(29-34)(30-35)(31-35)
Measurements (19)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| KB-3-1 | 0.92 | — | 10.1021/jacs.7b08640 | 2017 |
| HeLa | 1.2 | — | 10.1021/jacs.7b08640 | 2017 |
| KBCP20 | 1.6 | — | 10.1021/jacs.7b08640 | 2017 |
| A2780 | 2.2 | — | 10.1021/jacs.7b08640 | 2017 |
| A2780-CP70 | 3 | — | 10.1021/jacs.7b08640 | 2017 |
| MRC-5 | 4.1 | — | 10.1021/jacs.7b08640 | 2017 |
| HeLa | 4.4 | — | 10.1002/chem.201902223 | 2019 |
| NCI-H460 | 4.5 | — | 10.1021/jacs.7b08640 | 2017 |
| H460cisR | 5.3 | — | 10.1021/jacs.7b08640 | 2017 |
| A549cisR | 5.4 | — | 10.1021/jacs.7b08640 | 2017 |
| A2780 | 5.7 | — | 10.1002/chem.201902223 | 2019 |
| A2780-CP70 | 6 | — | 10.1002/chem.201902223 | 2019 |
| MDA-MB-231 | 6 | — | 10.1016/j.jinorgbio.2022.11209... | 2023 |
| A549 | 6.7 | — | 10.1021/jacs.7b08640 | 2017 |
| A549 | 7.7 | — | 10.1002/chem.201902223 | 2019 |
| A2780 | 8.5 | — | 10.1002/anie.202004883 | 2020 |
| HEK293 | 9 | — | 10.1002/chem.201902223 | 2019 |
| HEK293 | 20 | — | 10.1016/j.jinorgbio.2022.11209... | 2023 |
| A2780TR | 32 | — | 10.1002/anie.202004883 | 2020 |
🧬 Cell Death Types (2)
Apoptosis
high
«Flow cytometry and immunostaining experiments indicate TRIP induces intrinsic apoptosis. Additionally, the pan-caspase inhibitor Z-VAD-FMK significantly decreased TRIP's cytotoxicity, and western blot...»
Autophagy
high
«After 24 h, a large increase in LC3II expression relative to LC3I was observed in cells treated with TRIP... Based on these results, it is clear that TRIP induces both autophagy and apoptosis.»
Source-assisted 2D generator
Builds the drawing from source ligand graphs and explicit donor metadata, then uses Metal2D only for layout. Publication output uses black bonds without arrows or colour highlighting; validated octahedral enantiomers are encoded directly with solid and hashed wedge bonds.
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