Info
| ID | 616 |
| Metal | Ru |
| Oxidation state | 2 |
| Charge | 2 |
| Donor atoms | {"N": 7} |
| Abbreviation | KQ-Ru |
| SMILES | O=C(O)c1cc2c([nH]c3ccccc32)c(-c2ccc3ccccc3n2)n1.c1ccc(-c2ccccn2)nc1.c1ccc(-c2ccccn2)nc1 |
TUCAN
C41H29N7O2Ru/(1-56)(2-57)(3-31)(4-32)(5-52)(6-38)(7-36)(8-37)(9-30)(10-39)(11-40)(12-49)(13-35)(14-33)(15-51)(16-44)(17-45)(18-58)(19-43)(20-46)(21-59)(22-50)(23-41)(24-42)(25-34)(26-48)(27-47)(28-71)(29-79)(30-31)(30-32)(31-56)(32-63)(33-35)(33-57)(34-42)(34-58)(35-36)(36-64)(37-39)(37-69)(38-40)(38-52)(39-44)(40-61)(41-50)(41-60)(42-43)(43-67)(44-45)(45-55)(46-48)(46-68)(47-48)(47-59)(49-52)(49-53)(50-55)(51-54)(51-62)(53-54)(53-61)(54-65)(55-69)(56-72)(57-73)(58-74)(59-75)(60-66)(60-77)(61-71)(62-70)(62-76)(63-64)(63-72)(64-73)(65-66)(65-71)(66-76)(67-68)(67-74)(68-75)(69-77)(70-78)(70-79)(72-80)(73-80)(74-80)(75-80)(76-80)(77-80)(79-80)
Measurements (5)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| HepG2 | — | — | 10.1002/smll.202310636 | 2024 |
| A549 | — | — | 10.1002/smll.202310636 | 2024 |
| B16-F10 | — | — | 10.1002/smll.202310636 | 2024 |
| MCF-7 | — | — | 10.1002/smll.202310636 | 2024 |
| HL-7702 | — | — | 10.1002/smll.202310636 | 2024 |
🧬 Cell Death Types (2)
Apoptosis
high
«Within the lysosomes, KS-Ru self-assembled into nanoflowers, leading to lysosomal swelling and apoptosis.»
Immunogenic Cell Death
high
«Several DNA-damaging antitumor agents, including ruthenium complexes, induce immunogenic cell death (ICD). ... KS-Ru translocates to the nucleus, causing DNA damage and inducing ICD.»