Info
| ID | 6154 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 4, "O": 3} |
| Abbreviation | 8 |
| SMILES | Cc1cc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)sc1C.O.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C22H14N4O3ReS/(1-15)(2-26)(3-20)(4-16)(5-21)(6-16)(7-15)(8-16)(9-19)(10-15)(11-17)(12-18)(13-25)(14-38)(15-35)(16-23)(17-18)(17-22)(18-25)(19-23)(19-36)(20-21)(20-26)(21-24)(22-27)(22-30)(23-35)(24-28)(24-29)(25-37)(26-39)(27-29)(27-38)(28-30)(28-39)(29-40)(30-37)(31-36)(31-38)(31-40)(32-41)(33-42)(34-43)(35-44)(36-44)(39-45)(40-45)(44-45)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 0.41 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| RPE-1 | 1.8 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»