Info
| ID | 6153 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"N": 5, "O": 3} |
| Abbreviation | 7 |
| SMILES | Brc1csc(-c2nc3c4cccnc4c4ncccc4c3[nH]2)n1.O.[C-]#[O+].[C-]#[O+].[C-]#[O+] |
TUCAN
C19H8BrN5O3ReS/(1-15)(2-9)(3-11)(4-16)(5-10)(6-12)(7-25)(8-30)(9-11)(9-14)(10-12)(10-13)(11-15)(12-16)(13-17)(13-19)(14-18)(14-20)(15-31)(16-28)(17-20)(17-30)(18-19)(18-31)(19-28)(20-32)(21-26)(21-30)(21-32)(22-33)(23-34)(24-35)(25-27)(25-36)(26-29)(26-36)(27-29)(27-37)(31-38)(32-38)(36-38)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 1.4 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| RPE-1 | 4.2 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»