Info
| ID | 6152 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"O": 3, "N": 4} |
| Abbreviation | 6 |
| SMILES | O.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc2sc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)cc2c1 |
TUCAN
C24H12N4O3ReS/(1-19)(2-14)(3-20)(4-15)(5-21)(6-13)(7-18)(8-16)(9-26)(10-17)(11-25)(12-38)(13-20)(13-22)(14-22)(14-36)(15-16)(15-24)(16-26)(17-18)(17-25)(18-23)(19-20)(19-21)(21-35)(22-35)(23-27)(23-30)(24-28)(24-29)(25-40)(26-37)(27-29)(27-39)(28-30)(28-37)(29-38)(30-40)(31-36)(31-38)(31-39)(32-41)(33-42)(34-43)(35-44)(36-44)(39-45)(40-45)(44-45)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 0.05 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| RPE-1 | 0.65 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»