Info
| ID | 6151 |
| Metal | Re |
| Oxidation state | 1 |
| Charge | 1 |
| Donor atoms | {"O": 3, "N": 4} |
| Abbreviation | 5 |
| SMILES | O.[C-]#[O+].[C-]#[O+].[C-]#[O+].c1ccc2c(c1)Cc1cc(-c3nc4c5cccnc5c5ncccc5c4[nH]3)ccc1-2 |
TUCAN
C29H16N4O3Re/(1-21)(2-19)(3-22)(4-20)(5-26)(6-28)(7-18)(8-28)(9-25)(10-17)(11-23)(12-27)(13-37)(14-24)(15-36)(16-47)(17-18)(17-36)(18-30)(19-20)(19-31)(20-35)(21-22)(21-37)(22-29)(23-25)(23-32)(24-27)(24-34)(25-27)(26-33)(26-35)(28-32)(28-33)(29-38)(29-39)(30-40)(30-41)(31-33)(31-34)(32-34)(35-42)(36-46)(37-49)(38-41)(38-48)(39-40)(39-49)(40-46)(41-47)(42-47)(42-48)(43-50)(44-51)(45-52)(48-53)(49-53)
Measurements (2)
| Cell line | IC₅₀ dark (µM) | IC₅₀ light (µM) | DOI | Year |
| PC-3 | 0.03 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
| RPE-1 | 0.27 | — | 10.1021/acs.inorgchem.3c00730 | 2023 |
🧬 Cell Death Types (1)
Apoptosis
high
«for complex 6, a concentration-dependent induction of apoptosis was observed (Figure 11). However, the amount of apoptosis induction by 6 was very low, suggesting that apoptosis may not be a major pat...»